Determination of Release Mechanism from Multiple Coefficients&in vitro Release Kinetics of Metformin Hydochloride alone and along with Herbal Sex Stimulants ? Trends for Herb-Drug Interactions

Type-2 diabetes patients suffer from decreased libido in their early life, these patients take the oral hypoglycemic drug and herbal sex stimulant to control the diabetes as well as to increase the libido. The combined use of herbs and drugs has increased the possibility of herb-drug interactions. The study was undertaken to explore the herb-drug interactions. The investigation was done by in vitro dissolution test of Metformin HCl in absence or presence of herbal sex stimulants available in local market. Different mathematical models were adopted to explore the release kinetics. In this study higher percent release of Metformin HCl observed in presence of herbal sex stimulants, but the increase was not significant. The highest percentage of release was found at simulated intestinal medium pH 6.8 and at pH 4.5 in compared to simulated gastric medium pH 1.2 for Metformin HCl alone and Metformin HCl in presence of herbal sex stimulants. From the multiple coefficients determination data of Metformin HCl and Metformin HCl in presence Herbal Sex Stimulants it was observed that the Higuchi release kinetics was predominated at pH 1.2, but in case of pH 4.5 and 6.8, the first order release kinetics was predominated. Increased release pattern of Metformin HCl by administration of herbal sex stimulants gives better absorption, which gives us an idea that if we take these two drugs concurrently there will be no hazardous effect from each other.