In Vitro alpha- Amylase Inhibitory Activity and GC- MS Analysis of Petrea volubilis

One of the therapeutic approaches which involve decreasing hyperglycemia aims at inhibiting the enzyme -amylase. The aim of the present study was to investigate the in vitro anti-diabetic activity of the methanolic extract of Petrea volubilis. The assay results showed that the extract exhibit the dose-dependent increase in inhibitory effect on alpha-amylase enzyme upto 81.57 % with IC 50 value 24.750.294 g/ml. GC- MS analysis of root sample suggests that 1, 2-Benzenedicarboxylic acid, mono (2- ethylhexyl) ester compound may be responsible to decrease hyperglycemia. This study shows that the roots of Petrea volubilis were most effective in inhibiting -amylase, thereby proving to be potential anti-diabetic agents.