A Comparative Study between Timolol and Timolol in Combination with Newer Anti Glaucoma Drugs in the Treatment of POAG

The aim of study was to compare the IOP lowering efficacy of timolol and timolol with fixed combination therapy with latanoprost and dorzolamide. Study was undertaken in 60 patients attended to ophthalmology OPD, GGH, Guntur. They were randomly divided into three groups.20 patients in Group I treated with timolol.20 patients in Group II treated with fixed combination of timolol with latanoprost.20 patients in Group III treated with fixed combinationof timolol with dorzolamide. Thorough history was taken and patients underwent a comprehensive ocular examination i. e, visual acuity recording, slit lamp examination, gonioscopy, fundus examination with +78 D, +90 D lens, Goldmann applanation tonometry, visual fields recording on Humphreys field analyser. All the patients were followed up to six months. Percentage of reduction in IOP from baseline to 12th week was observed as Group I- 26 % (timolol) Group II-38 % (timolol+ latanoprost) Group III-35 % (timolol+ dorzolamide)