Microwave-Assisted Synthesis and Biological Activities of Some Chromene Derivatives

A series of 4H-chromene derivatives were synthesized under microwave irradiation, a comparative study was done depending upon yield and time. The present study reveals the synthesis of chromene derivative in which pyrazine-2-ol was reacted with chloroethylacetate in presence of K2CO3 to form an intermediate which was further treated with hydrazine hydrate to form hydrazino derivative of pyrazine-2-ol and finally the intermediate is condensed by substituted chromene derivatives to form final compound conventionally as well as by using microwave irradiation technique. The synthesized compounds were then characterized by using FT-IR, 1H-NMR and Mass spectrophotometer. All the compounds were screened for their anti-microbial activity, anti-oxidant and anti-inflammatory activity. It was found that the derivatives showed moderate activity as compared to standard.