Combination of Plasma Ultra-Sensitive CRP and Homocysteine as Diagnostic and Predictive Protocol for Acute Myocardial Infarction

Objective The aim of the present study was to provide us-CRP test together with homocysteine test as a protocol for emergency diagnosis for acute myocardial infarction (MI) comparing to cTnI and LDL-C. Materials and Methods This was a cross-sectional study conducted in Sudan, between December 2012 and July 2014. The study included 122 patients (78 males and 44 females). All the patients were admitted in Intensive Cardiac-Care Unit (ICCU) ward, and informed consent was obtained with the blood samples immediately (within the first 3 hours after chest pain), regardless the type of that disease. Control group was consisted of 80 healthy volunteers. Using enzyme linked immunosorbent (ELISA) method we estimated serum homocysteine (Hcy), ultra-sensitivity C - reactive protein (us-CRP), and cardiac troponin I (cTnI), while low-density lipoprotein (LDL-C) is measured by Standard direct automated spectrophotometric method. During the next 24 hours, and as a result of the medical follow-up, the patients were divided into 2 groups, AMI group (68 patients) and non-AMI group (57 patients). Results The levels of us-CRP in AMI group showed significant increasing (Pless than0.05) when compared to non-AMI group, as well as comparison with the control group. While Hcy and cTnI displayed a significant increase in AMI when compared to control but showed insignificant raise when compared to non-AMI. On the other hand, the level of LDL-C showed insignificant variations between the three groups. Conclusion Measurement of CRP together with homocysteine is thus a clinically sensible way to urgent and emergent assess whether a particular patient has acute MI than non-acute MI.