Effect of Scoparia dulcis (Linn.) and Aerva lanata (Linn.) Whole Plant and Fruit Part Extracts on Ethylene Glycol Induced Urolithiasis in Male Albino Rats

The potential of two commonly used phytotherapeutic agents such as Scoparia dulcis (Linn. ) and Aerva lanata (Linn. ) in the management of Calcium oxalate urolithiasis has been studied in male albino rats. Oral feeding of Ethylene glycol resulted in hyperoxaluria, increased renal excretion of calcium, phosphate and decreased level of magnesium, uric acid, citrate, creatinine as well as increased level of serum uric acid and creatinine. The pH level also decreased in Ethylene glycol administered rat urine. Administration with aqueous extract of whole plant and fruit part of Scoparia dulcis and Aerva lanata gradually reduced the stone constituents and increased the stone inhibiting constituents. Comparatively animal group supplemented with fruit part of Scoparia dulcis in combination with Aerva lanata showed significantly reduced stone forming constituents and increased stone inhibiting constituents. This indicates that the fruit part of Scoparia dulcis in combination with Aerva lanata is endowed with higher antiurolithiatic activity than others.