Immunomodulator Effects of Azithromycin, Ciprofloxacin and Ceftriaxone on Cross - Reaction between Widal Test and Anti-Helicobacter Pylori Igm in Acute Typhoid Fever

It has been well known that some antibiotics and other chemotherapeutic agents poses in addition to their antibacterial activity some other effects, like immunomodulation that improve long term outcome effects in chronic inflammatory disorders. The aims of present the study were evaluation the immunomodulation effects of azithromycin, ciprofloxacin and ceftriaxone on cross reactivity between widal and anti-helichobacter pylori in acute typhoid fever therapy. Thirty newly diagnosed typhoid fever patients, the patients divided into three groupsgroup (A) treated with azithromycin 500mg /day, group (B) treated with ciprofloxacin 500mg/day, group (C) treated with ceftriaxone 1g/day, the duration of therapy was 14 days then after two weeks a second 10 ml venous blood samples were collected for determinations the differential effects of drugs on cross reactivity between Widal test and anti-helicobacter pylori antibodies after two weeks of treatment termination. Both azithromycin and ciprofloxacin lowers anti-helicobacter pylori and Widal test IgM but ceftriaxone only decreased IgM related to Widal test but not to anti-helicobacter pylori. Conclusion Azithromycin, ciprofloxacin and ceftriaxone modulates and attenuate Widal test cross reactivity with anti-helicobacter pylori IgM.