Serum Insulin and Lipid Profile in Polycystic Ovary Syndrome

Polycystic ovarian syndrome (PCOS) has been one of a major public health problem in Sudan that leads to medical consequences. It causes multifactorial in etiology such as menstrual dysfunction, hyperandrogenism, hirsutism, dyslipidemia and obesity which increased risk of diabetes mellitus and cardiovascular disease. Objective The aim of this study was to investigate the concentration and potential role of insulin and lipid levels in Sudanese women with PCOS. Materials and Methods This study was a descriptive, analytic, cross- sectional and hospital-based study, carried in Khartoum- State- Sudan, it was carried out in March 2013 to May 2014.200 women with PCOS were enrolled in this study, they compared with 100 healthy women as control group, all of them were age-and weight-matched, Samples were taken after overnight fasting then serum insulin and lipid levels were analyzed using ELISA technique and enzymatic colorimetric methods. Data management and analysis was done by using Microsoft excel and SPSS software, version 20.00. Results The patients with PCOS, having a mean age of 29.61 5.4 years and mean age 31.234.93 years of control group, were included in the study, lipid profile parameters in PCOS group the (mean SD) of serum insulin, triglyceride, total cholesterol, HDL and LDL were11.066.21 IU/ml, 89.8933.36 mg/dl, 166.9546.9 mg/dl, 43.8320.75mg/dl and 104.5552.209 mg/dl, respectively while that of control group, the (mean SD) of serum insulin, triglyceride, total cholesterol, HDL and LDL were 4.521.60 IU/ml, 82.1326.51 mg/dl, 145.1431.019 mg/dl, 51.0214.81 mg/dl, and 72.6230.04 mg/dl, respectively. There was statistically significant increased levels of triglyceride, total cholesterol and LDL-C in PCOS group when compared to the control group (Pless than0.05). With decreased level of HDL-C. Conclusion PCOS patients had significant increased levels of serum insulin and altered lipid profile, there was hyperinsulinemia, which may be feature of insulin resistance (IR), and dyslipidemia which is associated with obesity and cardiovascular disease.