Impact of Oxidative Stress on Reproductive Hormones in Fertile and Non-Fertile Females

The reproduction in human is a very complex process which include appropriate working of both male as well female reproductive system and the various hormones of the system. Free radicals are involved in many metabolic disorders such as hypertension, diabetes, cancer, Chronic obstructive pulmonary disorders, kidney the disorders, rheumatoid arthritis, atherosclerosis, asthma. Increased free radicals in the body cause oxidative stress. Oxidative stress also impacts the reproduction. This study is designed to study the effect of oxidative stress on the female reproductive hormones. To achieve this aim 500 married female of reproductive age 25-35 yrs having no history of any metabolic disorder were included in the study. Thus the level of the oxidative stress marker MDA and the reproductive hormone i. e. estrodiol, progesterone and follicle stimulating hormone (FSH) (during different phases of ovulation by) were measured ELISA method. The level of the three hormones was measured during follicular phase, mid leutal phase and leutal phase. In the study, the level of the three hormones in different phases of ovulation was found to be significantly (pgreater than0.0001) increased in fertile group in comparison to the infertile group. On the other hand the MDA was found to be decreased (pgreater than0.0001) in the infertile group in comparison to the fertile group. Thus with this study it may be concluded that the oxidative stress impacts the female reproductive system and may be the reason of pathophysiology of infertility in the females.