Cytoarchetectural Changes in Cerbral Cortex Toxicated With Dimethoate in ALBINO RAT

Dimethoate (DM) is an organophosphate insecticide, has been used worldwide in agriculture and domestic for several years which has led to variety of negative effects in non target species including humans. Therefore, the present study investigated the acute oral sub lethal dose of Dimethoate on Cytoarchitecture of cortex region of brain viz. , Cerebral cortex. The LD 50of dimethoate (330 mg/kg BW) was evaluate by probit analysis method (Finney, 1971). Albino rats were divided in to 4 groups with group I serving as control, whereas II, III and IV groups were given ( 1/10 th LD 50i. e. , 330 mg/ kg bw) orally single, double and multiple doses of Dimethoate respectively. After stipulated time period the rats were sacrificied by cervical dislocation and the brain tissues was isolated at cold conditions. The neuro histopathological changes were observed through light microscope. The changes in different brain regions were in time and days dependent manner.