Specific Relevance of Laboratory Examinations in Patients with Chronic Hepatic Disease-Our Experience

Introduction. Main causes of chronic lesions and hepatic cirrhosis are alcohol and viruses. Indicators of fibrosis and other laboratory examinations find application in chronic hepatic lesions and in cirrhosis. Comparative selection of these indicators is irreplaceable in treatment, monitoring and prognosis Aim. Features of selected laboratory examinations as cholesterolemia (Chol), trigliceridemia (Tri), chanaliculi enzymes ALP (alkaline fosfataza), GGT (gamaglutamil transferase) in patients with chronic hepatic lesions including cirrhosis, and observation and usefulnes of index of fibrosis that takes into account ALT and platelets. Material and Methods. Fibrosis index is calculated in 30 normal patients, 16 patients with chronic etilizem, 26 with ethyl cirrhosis and 24 with viral cirrhosis. Also, among these groups, is compared kolesterolemia, trigliceridemia, alkaline phosphatase and gamaglutamiltransferase. Results Fibrosis index Control group0.1880.1 compared with ethyl cirrhosis 0.9980.877 ( pless than0.0001, Cirrhosis 2.112.6 compared with chronic ethylism 0.4630.385 (p=0.0014), Ethyl cirrhosis compared with chronic ethylism (p=0.034), viral cirrhosis 3.273.29 compared with ethyl cirrhosis 0.9180.877 ( pless than0.017), Cholchronic ethilism=18648.9, ethyl cirrhosis 11741.7 (pless than0.0001), viral cirrhosis= 99.953.2, ethyl cirrhosis (p=0.24) Trichronic ethylism =80.332.9, Ethyl cirrhosis=92.955 (p=0.47), viral cirrhosis=78.935.2, ethyl cirrhosis (p=0.32) GGT chronic ethilism=119122, ethyl cirrhosis=98.386.8 (p=0.51), viral cirrhosis compared with ethyl cirrhosis (p=0.27), ALP viral cirrhosis=16087.5 ethyl cirrhosis=12446.4 (p=0.089) chronic ethylism= 67.816.8, ethyl cirrhosis 12446.4 (p=0.0001). Conclusions. Index of fibrosis, chol but not Tri, ALP but not GGT, depend on the stage of the lesion histopathology of liver. Index of fibrosis, give us additional information to medical decision making in chronic hepatic lesions, including cirrhosis.