The Prophylactic Role of Tranexamic Acid to Reduce Blood Loss during Radical Surgery: A Prospective Study

Background The radical surgical procedures are associated with perioperative blood loss. This study was aimed to evaluate the clinical efficacy and safety of tranexamic acid in reducing perioperative blood loss in patients undergoing radical surgery. Materials and Methods 20 ASA class I and II adult consented patients, scheduled for elective radical surgery and met the inclusion criterion, were blindly randomized into two groups to receive either intravenous 1 g tranexamic acid 20 min before skin incision or an equivalent volume of normal saline as placebo (P). All patients- total blood loss was measured and recorded perioperatively at the 12 th h postoperatively. The preoperative and postoperative hemoglobin, hematocrit values, serum creatinine, prothombin time, and symptoms of pulmonary embolism were comparatively evaluated. Conclusion The prophylactic administration of tranexamic acid has effectively reduced the blood loss and transfusion needs during radical surgery without any adverse effects or complication of thrombosis