The Histopathological Study on Helicobacter pylori Associated Gastroduodenal Diseases in a Tertiary Care Hospital, Mysore

Gastroduodenal diseases are common disorders which are known to be caused by Helicobacter. pylori. Histopathological study is the mainstay in the diagnosis of H. pylori. The study sets out to evaluate histopathological diagnosis of gastric biopsy and to correlate histopathological and endoscopic findings. A total of 48 biopsy samples were studied retrospectively using revised Sydney system. Antral biopsies were stained with Haemtoxylin and eosin for light microscopy. Giemsa was done wherever necessary. Among 48 patients 36 were males and 12 were females (31). Histopathology revealed varying degrees of chronic gastritis, with or without H. pylori, activity, intestinal metaplasia and atrophy. Out of 48 patients, 35/ (72 %) were histopathologically positive for H. pylori. Endoscopic findings revealed 13 (27 %) duodenal ulcer cases, 9 (18.7 %) gastric ulcer cases, 4 (8.3 %) gastroduodenal ulcer cases and 16 (33.3 %) erosions. Endoscopic findings of 6 (12.5 %) patients revealed normal picture. In conclusion, Endoscopic and histopathological examination go hand in hand in the diagnosis of gastro duodenal diseases. This study emphasizes the necessity of correlating histopathological findings with the endoscopic impression.