Antibacterial Activity of Some New Compounds of Sarcococcasaligna
Journal: International Journal of Science and Research (IJSR) (Vol.4, No. 7)Publication Date: 2015-07-05
Authors : Tahira Moeen Khan; Ismat Naeem;
Page : 2527-2529
Keywords : Sarcococca saligna; Buxaceae; steroidal alkaloid; antibacterial alkaloid; Sracosalgmine; Sracosalgminol; Sracosalgnenone; 14-15 dehydrosarcovagine-D;
Abstract
Pharmacological studies of S. saligna revealed that the crude ethanolic extracts of S. saligna (aerial parts) and roots were cytotoxic and antibacterial but produced no platelet aggregation induced by ADP. Antibacterial activity of four alkaloids (compounds) was determined for the first time against 11 bacterial strains. Compound 1 (Sracosalgmine) showed moderate activity against Shigella boydii, Klebsiella pneumoniae. Compound 2 (Sracosalgminol) showed less activity with Staphylococuss aureus and Streptococus pyrogens. Compound 3 (sracosalgnenone) and Compound 4 (14-15 dehydrosarcovagine-D) were inactive against all bacterial strains
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