Antibacterial Principles of Salacia oblonga WALL Extracts against Drug Resistance Pathogens

Salacia oblonga Wall containing vital phytoconstituents viz. mangiferin, salacinol, kotanolol etc has been in used since long in the treatment of diabetes, inflammation and burn wounds. The antimicrobial activity of S. oblonga aerial and root parts has been tested against drug resistant pathogens staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae. Ethyl acetate extracts of S. oblonga parts have shown significant growth inhibition. Further the extract was fractionated by thin layer chromatography (TLC) and silica gel column chromatography. The active fractions from the chromatography displayed growth inhibition against drug resistant pathogens. Our study provides baseline information for the potential use of plant extracts to fight against drug resistant human pathogen.