66 kDa Protein Isolated from 24,000 g Fraction of Plasmodium berghei Exhibits Humoral Immune Response
Journal: International Journal of Science and Research (IJSR) (Vol.4, No. 8)Publication Date: 2015-08-05
Authors : Nisha Devi; H. S. Banyal;
Page : 1579-1583
Keywords : Plasmodium berghei; malaria; 24; 000g fraction; 66 kDa protein;
Abstract
The various antigens involved in the induction of humoral immune response provide the opportunity for development of an effective malaria vaccine. In the present study, the immunogenicity and protective efficacy of 24, 000 g fraction was evaluated in rodent mouse model. A 66 kDa protein was eluted through immunoadsorption using 24, 000g fraction. The eluted protein was characterized by SDS-PAGE and mice immunized exhibited strong humoral immune response analysed by ELISA, IFA, DOT-ELISA and in vitro invasion inhibition assay. About fifty percent inhibition of parasite propagation was observed in vitro. This protein appears to be an important constituent of the parasite for antimalarial studies.
Other Latest Articles
- Autism in Children: A Literature Review
- Social Capital Contribution in Development of Marine Ecotourism in Tomia Island Wakatobi National Park
- A Region Boundaries Algorithm for Ear Authentication Based on Plots
- A Study of Beliefs of Teacher Educators About Relationship between Teaching And Research
- Physical and Structural Characterization of Chromium Ions Doped SrO-Li2O-CaO-B2O3 (SLCB) Glasses
Last modified: 2021-06-30 21:52:09