The Role of Inflammation in the Benign Prostatic Hyperplasia Pathogenesis

Background This study aimed to analyze the role of proinflammatory cytokines TNF and anti-inflammatory IL-10 in the pathogenesis of benign prostatic hyperplasia. Methods This research is an correlative analytical study with validity test, comparing the levels of pro-inflammatory cytokines TNF- and anti-inflammatory mediators IL-10 with prostate volume in benign prostatic hyperplasia patients. Result Based on correlation test in BPH patients with prostatitis, prostate volume strongly relates with TNF and IL-10. This showed in the significant value of less than 0.05. So, TNF- and IL-10 has a strong relationship with the size of the prostate volume in BPH patients. There is tendency when the TNF- and IL-10 increased, prostate volume is also increased. Based on the normality data test for prostate volume, obtain result sig = 0.113greater than 0.05, that mean the data is concomitant with the normal distribution. Then analyzed by linear regression, the results showed that each increase of TNF 1 pg / ml, the prostate volume will also tend to increase by 3.345 ml. The value of R2 at 29.4 % provides that the effect of TNF to the prostate volume is 29.4 %, the remaining (70.6 %) is came from other factors. When the IL 10 increased 1 level, the prostate volume tends to increased by 1.196, the determination coefficient (R2) is 15 % which means that only 15 % of the effect of IL-10 on prostate volume, the remaining 85 % comes from other factors. Conclusion Levels of TNF- and IL-10 have a very strong correlation with the prostate volume in benign prostatic hyperplasia patient. If there is an increased of TNF-, the prostate volume will also increased. Same as IL-10. Inflammatory mediators play a role in the increasing of prostate volume and prostate proliferation cell inflammatory grading. So it can be concluded that chronic inflammation plays a role in the pathogenesis of benign prostatic hyperplasia.