Parkinson Disease Research: Distinct Animal Models and Therapeutic Approach

Recently, the treatment of Parkinson's disease has seen a considerable progress, nevertheless, due the numerous sides? effects of drug treatment, as well as the difficulty of neurosurgical therapy, it is important to multiply the researches in order to better understand the pathogenic mechanisms of this disorder and to identify new therapeutic strategies. Fortunately for us, animal models represent an important aid in the experimental medical sciences because they enable us to gain insight into the different mechanisms underlying the human's diseases, once validated, animal models may also help to test the therapeutic effects of some molecules, develop new drugs and eventually, identify new therapeutic pathway. However, it is slightly difficult to model neurodegenerative disease because of their variability and the ambiguity of their etiology, therefore, there is a real need to ameliorate the current animal models and to develop new ones. The aim of this paper is to review the different animal model of Parkinson's disease which have been developed over the years, and critically discuss their advantages and their limits. We will also suggest a possible new therapeutic approach for Parkinson's disease focusing on the involvement of the non-dopaminergic system in the occurrence of the disease.