Hepatocurative Effects of Methanolic Root Extract of Sodom Apple (C. PROCERA) on CCL4 Induced Hepatotoxicity Rats
Journal: International Journal of Science and Research (IJSR) (Vol.4, No. 11)Publication Date: 2015-11-05
Authors : G. U.; Kanya; Alhassan; A. J.; Shehu Z.; Fatima I. B.;
Page : 249-252
Keywords : Calotropis procera; hepatotoxicity; livolin; carbon tetrachloride;
Abstract
The effects of methanolic root extracts of C. procera and livolin on liver function indices of CCl4 induced hepatotoxicity rats was evaluated. Forty (40) albino rats were grouped into four (I, II, III and IV) of 10 rats each, 120mg/kg CCl4 was administered to rats in group II, III, and IV intramuscularly followed by oral administration of 10mg/kg livolin and methanolic root extract of C. procera to group III and IV respectively. Group I and II serves as positive and negative control. Analysis of variance (ANOVA) for multiple comparisms test were used to compare the result of the liver and kidney biochemical parameters from the test and control group at 10 days interval for 20 days. The hepatic biochemical markers alanine aminotransferase (ALT), Aspartate amino transferase (AST), alkaline phosphatase (ALP) of the toxicant group (Gp II) were significantly higher (Pless than0.001), while group III (treated with livolin) statistically decreased (Pless than0.05) when compared with control (Gp I), this confirms the toxicity and treatment with livolin respectively. Oral administrations of the extracts lower all the liver function markers and increase the concentration of urea and albumin. This show the hepatocurative effect of the extract against CCl4 induced rats. These effects may be due to the active components present in the root similar to those found in livolin.
Other Latest Articles
- Mapping Vessel Path of Marine Traffic Density of Port Klang, Malaysia using Automatic Identification System (AIS) Data
- Mining Sequential Patterns from Probabilistic with Source Level Uncertainty
- Efficient Implementation of Class Based Decomposition Schemes for Naive Bayes Classifier
- Access Control Model for Cloud Platforms Using Multi-Tier Graphical Authentication ? Research Paper
- A Dynamic Two key Factor Technique Security Adoption in WSN (Improved LEACH)
Last modified: 2021-07-01 14:26:37