A Clinical Study to Compare the Efficacy of Pretreatment with Granisetron and Lignocaine to Alleviate Pain on Propofol Injection

Pain on injection of anaesthetic is an important cause of patient dissatisfaction and a recognized adverse effect of propofol. Routinely, intravenous preservative free lignocaine is used for prevention of pain due to injection of propofol. In this study, granisetron a specific 5HT3 receptor antagonist was used to compare the efficacy.100 adult patients belonging to ASA physical status I or II, scheduled for elective surgeries under general anaesthesia were randomly allocated into two groups A & B. Group A received Inj lignocaine 30 mg and group B received Inj granisetron 2mg as pretreatment, before injection of propofol. Comparing pain during propofol injection, lignocaine and granisetron were found to decrease the injection pain significantly. Granisetron has less incidence of PONV.