Interspecies Variation in Pupation Site Preference on Exposure to Different Anti Epileptic Drugs - A Study in Few Species of Drosophila

The present work determine the acute adverse effects produced by commonly used conventional AEDs with respect to their larval pupation site preference in Drosophila species at different doses. Dose dependent action of different AEDs produced a maximal effect on behaviors of Drosophila species on exposure to phenytoin followed by valproiuc acid and carbamezepine which provides an efficient system to study genetic, neurological, and behavioral mechanisms. Such studies are useful for understanding the multiple effects on behavior. Larval pupation site preference is an important event in pre-adult development. Pupation site preferences of Drosophila larvae depend on species-specific cues. The present study revealed that the pupation site preference between species significantly varied on exposure to different AEDs and prefer media at large for pupation at high doses. D. melanogaster, D. ananassae and D. nasuta nasuta do not belong to same species group, but show similarity in their pupation site preference.