Correlation of Serum Magnesium with Lipid Profile in CKD Patients on Maintenance Hemodialysis

. This study was performed to determine the correlation between serum magnesium (Mg) and lipid profile in patients on maintenance hemodialysis (MHD). This hospital-based cross-sectional observational study was conducted at the Department of Medicine, Hamidia Hospital and Gandhi Medical College, Bhopal during period of May 2014 to Nov 2014. Fifty patients with end-stage kidney disease on MHD treatment (29 males and 21 females) were studied. The mean frequency being two to three sessions /week of hemodialysis and each session lasted for four hours. After obtaining informed written consent, the general information of each patient was recorded on a proforma. After overnight fasting, blood samples was drawn for complete hemogram, blood urea, serum creatinine, lipid profile and serum Mg. Dyslipidemia was defined as presence of total cholesterol (TC), triglyceride (TG) or low density lipoprotein (LDL) levels more than 95th percentile for age and gender or high-density lipoprotein (HDL) levels less than 35 mg/dL. Descriptive and inferential statistical analyses were performed using SPSS version 20.0. The mean age of the study patients was 45.46 15.60 years Serum magnesium in CKD patients significantly correlated with Age (Pless than 0.001), systolic blood pressure ( pless than0.001), serum Triglyceride levels (P=0.029), FBS ( p= 0.04) and Mean CIMT (pless than 0.01). There was no significant correlation between serum Mg and serum cholestrol and serum HDL. The serum TG and cholesterol levels were significantly increased while HDL-c was significantly lower in MHD patients. We conclude that serum magnesium correlated positively with HDL and correlated negatively with total cholesterol both insignificantly but had significant negative correlation with serum triglyceride levels. The abnormalities of lipid metabolism, such as hyper-triglyceridemia, elevated LP-a and low HDL-c, could contribute to atherosclerosis and cardiovascular disease in hemodialysis patients.