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Synthesis, Characterize and Antimicrobial Study of New Chalcones and Pyrazole Derivatives from Progesterone

Journal: International Journal of Science and Research (IJSR) (Vol.5, No. 3)

Publication Date:

Authors : ; ;

Page : 833-836

Keywords : Progesterone; Chalcone; Pyrazole; Antimicrobial; Biological activity;

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Abstract

The aim of this work synthesized a new series of chalcones and pyrazole derivatives from the progesterone, the new steroidal synthesized by the claisen-Schmidt condensation reaction, were react progesterone with different aromatic substituted aldehyde in presence sodium hydroxide afforded chalcones derivatives (1-6). Cyclized the chalcone derivatives by reaction with hydrazine hydrate to afforded pyrazole derivatives (7-12). All synthesized compounds were characterized by measurement melting point, FT-IR spectral, Elemental Analysis and some of them by 1H-NMR spectral and Antimicrobials activities.

Last modified: 2021-07-01 14:32:41