Spectroscopic Investigation on the Interaction between 4-Amino Salicylic Acid (PAS) with Bovine Serum Albumin (BSA)
Journal: International Journal of Science and Research (IJSR) (Vol.5, No. 4)Publication Date: 2016-04-05
Authors : Mamali Priyadarshinee; Bairagi C. Mallick;
Page : 573-576
Keywords : Bovine serum albumin BSA; 4-aminosalicylic acid PAS; fluorescence; FT-IR and CD spectroscopy;
Abstract
PAS (4-amino salicylic acid) is a potentialantimicrobial drug used for the treatment of Mycobacterium tuberculosisdrug resistance. Its interaction with bovine serum albumin (BSA) is important to understand the mechanism of drug-protein interactions and its effectiveness to treat the drug resistance. The binding of PAS with BSA, investigatedby UV-visible and fluorescence measurements clearly indicates the conformational stability of the protein, Further, FT-IR and CD spectroscopic methods support the results with inceasing secondary structure content of the protein in the presence of drug.
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