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Spectroscopic Investigation on the Interaction between 4-Amino Salicylic Acid (PAS) with Bovine Serum Albumin (BSA)

Journal: International Journal of Science and Research (IJSR) (Vol.5, No. 4)

Publication Date:

Authors : ; ;

Page : 573-576

Keywords : Bovine serum albumin BSA; 4-aminosalicylic acid PAS; fluorescence; FT-IR and CD spectroscopy;

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Abstract

PAS (4-amino salicylic acid) is a potentialantimicrobial drug used for the treatment of Mycobacterium tuberculosisdrug resistance. Its interaction with bovine serum albumin (BSA) is important to understand the mechanism of drug-protein interactions and its effectiveness to treat the drug resistance. The binding of PAS with BSA, investigatedby UV-visible and fluorescence measurements clearly indicates the conformational stability of the protein, Further, FT-IR and CD spectroscopic methods support the results with inceasing secondary structure content of the protein in the presence of drug.

Last modified: 2021-07-01 14:33:56