Modern Conceptions about Antibiotic Levorin A and its Derivatives Action in Cell and Bilayer Lipid Membranes

The group of polyene antibiotics represents phytogenesis drugs with wide spectrum of application against fungal infections. Among them amphotericin B, mycoheptin, nystatin and levorin are more applicable in clinical medicine. Clinical use of these antibiotics is based on their properties. They have small toxicity and may be use together with the tetracycline group, cytostatics and other medicines because these drugs may form consecutive infection (candidiases, aspergillosis and others). Thanks to good solubility in water and adsorbability polyene antibiotics in much smaller doses are very effective and can be applied in therapeutical purposes. As chemical substances they are macrolacton compounds and their molecules contain lacton macrocyclic ring with defined number of double bonds. Nevertheless the classification of these antibiotics divides for two subdivisions aromatic and non-aromatic ones. Aromatic antibiotics are small quantitative. These drugs have additional aromatic group. Among them more researched ones are candicidin and levorin. Hydrophobic part of a molecules has aromatic group- aminoacetophenon (1). As another polyene antibiotics levorin and its sodium salt are small toxic drugs. In the form of spray they dont cause changes of top airways, lungs and other internals.