Evaluation of Analgesic Activity of Paroxetine in Adult Male Albino Rats in Comparison with Diclofenac

BACKGROUNDPain affects millions of people, leading to depression and anxiety. Paroxetine is the most potent inhibitor of serotonin re-uptake. . The analgesic effect of Paroxetine has been shown both in animal models and human cases suffering from different type of chronic pain. OBJECTIVES OF THE STUDY To evaluate of analgesic activity of paroxetine in adult male albino rats in comparison with diclofenac METHODOLOGY The analgesic effect of graded doses of paroxetine (2.5mg/kg, 5mg/kg, 10mg/kg) was evaluated using Eddys hot plate method and tail-flick method and compared with the standard analgesic diclofenac. The values obtained are expressed as meanSEM. Statistical analysis of differences between groups was carried out using one-way analysis of variance (ANOVA). Probability (P) value of less than0.05 was taken as the level of statistical significanceRESULTS Paroxetine showed statistically significant analgesic activity in comparison with control group and standard group (P less than 0.05)