Atherogenic Index of Plasma and Insulin Resistance in Obese Diabetic Patients

Background many indicators show that lipid profiles with insulin resistance were associated with cardiovascular disease. the atherogeninc index now regard as a strong index for cardiac risk application. Aim of study this study was done to approve the importance of glycated hemoglobin (HbA1c) in predicting dyslipidemia and etherogenecity in obese and non-obese in type 2 diabetes. Subjects and methods The study consisted of (105) subjects, were dividing into three group, the first contain 50 obese DM, second group contain 35 non obese DM, and 30 as healthy control. Fasting plasma glucose, total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, and triglyceride (TG) levels were measured with an enzymatic colorimetric method, insulin and HbA1c were estimated by sandwich ELISA technique, Low-density lipoprotein (LDL), very low-density lipoprotein (VLDL) homeostasis model assessment (HOMA-IR) , Atherogenic Plasma index (AIP) and Atherogenic coefficient (AC) were calculated using special formula. Result the results of the study revealed a significant increase in BMI , wist/hip, FPG, insulin, HOMA, HbA1c, cholesterol, HDL, LDL, VLDL, TG, TC/HDL, LDL/HDL, AIP and AC, AIP has appositive significant correlation with wist/hip, HOMA, TG, and VLDL, while AC has appositive significant correlation with TC, TC/HDL, LDL/HDL and negative significant correlation with TG, and HDL. Also HbA1 show appositive significant correlation with BMI, FPG, LDL/HDL and negative significant correlation with wist/hip, VLDL in non-obese group Also this study show's appositive significant correlation of AC with BMI, TG, VLDL, TC/HDL and negative significant correlation with insulin. HbA1c was revealed appositive significant correlation with Age, FPG, insulin, HOMA, LDL, LDL/HDL, and negative significant correlation with BMI. AIP appeared appositive significant correlation with TG, LDL, VLDL, TC/HDL, and LDL/HDL in obese group Conclusion these results concluded that hyperglycemia and high level of HbA1c were associated with increased AIP and AC, these factors leads to increased risk of developing CVD.