Anti-inflammatory and Regenerative Effects of Albanian Propolis in Experimental vital Amputations in Piglets (Histological assessment)

This study evaluated the effects of Albanian propolis on the inflamed pulpal tissue after pulpotomy in piglets. Pulpotomy was made in the maxillary and mandibular central and lateral incisors. Microbial flora pathogenesis prepared from the section of infected teeth, containing Staphylococcus aureus, Streptococcus viridans, Enterococcus faecalis, Staphylococcus albus and mixed flora were used to cause artificial pulpitis. The first group consisted of piglets with teeth having pulpal inflammation and regeneration without medication served as a control group. In the second group, the teeth were treated with pure propolis after vital amputation. In the 3rd, 4th and 5th groups, the teeth were treated after vital amputation with the compounds of ZnO+10 %, ZnO+20 % propolis in ethanol, and with the paste composed of Ca (OH) 2+30 % oily propolis, respectively. Histopathology analyses were performed to survey the infected pulp tissue treated with propolis up to 3 months. After vital amputation of the pulp, application of Albanian propolis showed significantly higher anti-inflammatory and regenerative effect creating dentin barrier after 3 months of treatment compared to control group (pless than0.05). These results were more expressed in the group containing 20 % propolis in ethanol+ZnO.