Fibrosarcoma and Papillary Thyroidcarcinoma in Ratsadministred of Platinum Analogue Daily

Fibrosarcoma is a malignant mesenchymal neoplasm composed predominantly of fibromatosis like stroma in which small follicles are diffusely dispersed. Papillary thyroid carcinoma (PTC), predominantly growing in a solid growth pattern with papillary projections, and composed of oncocytic cells with Orphan annie eyes nuclei. Cisplatin or Cis-Diamminedichloroplatinum (ii) (Cl2H6N2Pt), it is a divalent, inorganic, water-soluble first successful platinum containing anticancer drug, used to treat various forms of cancers. However, the Carboplatin (C6H14N2O4Pt) 2nd generationandOxaliplatin 3rd generation (C8H14N2O4Pt) analogue of Cisplatin and arethe investigational chemotherapy medicine, which interferes with the genetic material or DNA inside the cancer cells and prevents them from further dividing and growing more cancer cells by forming interstrand and intrastrand cross-linking of DNA molecules. The intraperitoneal injection of 15mg/Kg BW (Group-A), 15 mg/Kg BW (Group-B), 15 mg/Kg BW (Group-C), among the three groups Group-A resulted in to fibrosarcomaor aggressivefibromatosis of the stroma, however, Group-B showed the formation of papillary thyroid carcinoma (PTC), Group-C did not show any above mentioned carcinomas. In the present study the PTC was characterized by follicles with empty colloid, cells were arranged in clusters, with nuclear crowding and overlapping, some cells still demonstrated a polygonal contour with well-defined central nucleus, finely granular, delicate, powdery chromatin presence of multinucleated giant cellsor a row of palisaded tumor cells with empty lumen.