Anti-Stress Effect of Morus alba Extract on Biochemical Parameters and Histology of Liver in Stressed Mice Induced by Epinephrine

Herbal medicine is the oldest form of healthcare known to mankind. Herbs had been used by all cultures throughout history. It was an integral part of the development of modern civilization. In the present investigation, we examined the Morus alba extract effect on epinephrine induced strees. Twenty four albino mice were divided into three groups as non stressed group and stressed group and extract treated group. The stressed groups were exposed to 2 weeks and 4 weeks of chronic immobilization stress with epinephrine. At the end of the 2 and 4 weeks the mice were sacrificed and blood samples were collected through orbital sinus method. The blood samples of these groups were analyzed for selected biochemical parameters viz. Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT), and Bilirubin which were found to be significantly increased in the stressed group when compared to the non stressed Control. The present data indicate that epinephrine induced stress causes the significant alterations in the SGOT, SGPT and Bilirubin levels affecting the normal metabolism in liver. These elevations were found to be significantly reversed in Morus alba extract treated group. Morus alba have a potent capacity to control anti-stress.