Protective Effects of 1-Deoxynojirimycin on the Liver Histopathological Injury of Diabetic Induced Mice

Diabetes mellitus is a metabolic disorder and affects nearly 10 % of the population every year. The aim of present study was to investigate the histological changes in diabetic Induced Swiss albino mice, Mus norvegicus albinus on exposure to 1-Deoxynojirimycin.1-Deoxynojirimycin is known to be a potent antidiabetic compound. The study was conducted on mice Swiss albino male mice, the animals were divided into six equal groups and each group comprising 5 animals. The 1st group was given distilled water and used as a control group. The 2nd and 3rd groups were normal mice they were orally administered with only 1-Deoxynojirimycin 40 mg/kg b. w. and 60 mg/kg b. w. respectively. The 4th group was used as a diabetic control which induced with Streptozotocin (STZ) to produce diabetes. The 5th and 6th groups were diabetic induced and administered 1-Deoxynojirimycin at the dose 40 mg/kg b. w. and 60 mg/kg b. w. respectively. The histological sectioning of tissue was followed as per the standard procedure. Photomicrograph of the section preparation was taken using Olympus (PM-6 Model) photomicrograph equipment. The results indicated that STZ treated mice exhibited severe liver degeneration and these changes were reversed on exposure to DNJ for a period of 30 days. The study exhibited that DNJ alleviated the hepatic histopathological changes induced by STZ.