Investigation of ActualRate of Primary and Mixed Infections with some TORCH Agents among Iraqi Gravidas with History of Recurrent Abortions

Viral and bacterial infections in pregnant women have long been known to play a critical role in pregnancy wastage and adverse fetal consequences in terms of recurrent and spontaneous abortions especially at the first trimester of gestation with the increasing risk of in-utero transmission. Aim of the study The correlate between the incidence of Rubella, CMV, HSV and Ct primary infection among first trimester gravidas with recurrent abortion, and estimating the rate of mixed infection with these agents. Materials and methods A cross-sectional study was carried out at the private laboratories of Wasit province/Iraq between September 2015-August 2016 serum level of Rubella, Cytomegalovirus (CMV), Herpes simplex virus 1and 2 (HSV) and Chlamydia trachomatis (Ct) antibodies were evaluated using enzyme-linked immunosorbent assay (ELISA) method and IgG avidity. Results 82 serum samples were collected from gravidas in their first trimester, the study group included 67 (81.7 %) gravidas suffering from previous history of recurrent abortions. High rate 31 (46.27 %) of study group were suffering from 1time abortion. the lowest rate7 (10.45 %) were for gravidas with 4times abortion. The control group included 15 (18.3 %) gravidas with no history of abortion and healthy pregnancy. The rate of primary infection among group1 arranged as follow high rate of Ct infection (16.42 %) followed by CMV, HSV and Rubella primary infection (14.92 %, 5.97 % and 4.48 % respectively). Conclusion Early and accurate diagnosis of TORCH agents in first trimester will aid in management of infection especially Ct which infect all ages recurrently. Using of IgG avidity test will decrease false positive results and aid in management of Rubella and CMV and lower the risk of in-utero transmission of infection.