Management of Lower Ureteric Calculi with Alfuzosin, Tamsulosin and Tamsulosin Deflazacort Combination: An Observational Study

Study objective To observe the efficacy of alfuzosin, tamsulosin and tamsulosin-deflazacort combination in the medical expulsive therapy of lower ureteric calculi. Methods The observational comparison study was done at FATHER MULLER Medical College hospital over a period of 9 months from Jan 2016 to Sept 2016, a total sample size of 128 admitted patients was be taken. After initial assessment as per the individual consultants choice patients were put on any of the three groups drugs Alfuzosin 10mg, Tamsulosin 0.4mg or Tamsulosin 0.4mg - deflazacort 30mg in conjunction with Medical Expulsive therapy (MET). Each patient was subjected to two sessions of MET and were radiologically assessed for stone passage with NECT-KUB. Those with a persistent calculus were taken up for lithotripsy. Results Of 543 patients considered for the observational study only 128 were found eligible.68 patients were put on alfuzosin 10mg, 39 were put on tamsulosin 0.4mg and 21 were put on tamsulosin 0.4mg deflazacort 30mg combination. Due to the non comparative nature of the three groups, no statistically significant conclusions could be drawn. However, In patients with calculi greater than 7mm, 50 % of the patients passed the calculus in the tamsulosin-deflazacort group vs 30 % in tamsulosin group and 20 % in the alfuzosin group. No difference was noted in efficiency of either of the drugs in clearance of small calculi