Eosinophilic Responses to the Parasitaemia of Plasmodium Falciparum Treated Malaria In Children, Lake-Alau, North Eastern Nigeria

This study assessed the recovery patterns of children (6-59 months) from malaria using the relationship between eosinophils concentration and parasite densities trends. Two groups where were treated for malaria infections, namely, Artesunate + Sulphadoxine-Pyrimethamine (AT+SP) or Amodiaquine + Sulphadoxine-Pyrimethamine (AQ+SP) in uncomplicated Plasmodium falciparum for 28 days, using the standard therapeutic protocols of the World Health Organization. The results shows a weak association between eosinophil concentrations and parasite densities over segments of the study period of days 0 - 28 using the two combination drugs. The results show r-values of 0.2848 versus 0.1207 for AT+SP versus AQ +SP, respectively. There was higher mean eosinophillic elicitation in AQ+SP (b-values = 0.4137) compared to AT+SP (b-value = 0.2037). The results also shows an eosinophilic reduction with parasite depletion in general but concentration at enrollments were close and marginal for both AT+SP (8.8959 %) and AQ+SP (8.4545 %) patients. The effect of parasitaemia on eosinophils was generally low for both drugs which ranged from 7.12 % for AT+SP to 12.07 % for AQ+SP patients.