Comparative Evaluation between Blend from Beta-Sitosterol and Chitosan with Ration (2:1) and Rosuvastatain on Plasma Lipid Profile Changes in Hypercholesetrolemic Rabbits

The purpose of the present survey was to determine the effects of the Blend from -Sitosterol and Chitosan with ration (21) and rosuvastatain on plasma lipid profile changes and the influence of time on treatment process in rabbits. For the management of cholesterol induced hyperlipidemia. Eighteen healthy rabbits were randomly divided into three equal groups Group A (control) included six rabbits that were fed with cholesterol powder (0.5 g/kg B. W for 2 weeks). Group B was similar group A, but in addition rosuvastatain (0.4mg/kg) was administrated for 4 weeks after induced hyperlipidemia. Group C was similar to B, but blend (0.07g/kg B. W) was administered instead of rosuvastatain. Blood samples were collected from ear margin vein by using insulin syringe (2ml) and transferred into EDTA tubes immediately. Blood was then centrifuged at (402 Xg for 10 minutes) to remove red blood cells and recover plasma, this plasma sample was used in biochemical measurements total cholesterol TC, triglycerides TG, high density lipoprotien HDL levels were measured using standard commercial Kits. Rosuvastatain (pless than0.01) and blend (pless than0.001) showed more hypolipidemic activity in lowering low density lipoprotien compared with group A. In acomparison between two drugs and their effects on TG, rosuvastatain showed a significant difference with blend (pless than0.001) Rosuvastatain (pless than0.01) and blend (pless than0.001) showed more activity in lowering cholesterol than the control group. The treated groups B and C had good results in lowering LDL, compared with group A, on 4 weeks (pless than0.001). Asignificant difference was seen only between group A and C and on 4weeks in increase of HDL (pless than0.01). In conclusion, it was shown that although both drugs had hypolipidemic activity in rabbits blend from -Sitosterol and Chitosan with ration (21) was more effective than rosuvastatain.