High Level of Maternal Low Density Lypoprotein and Insulin-Like Growth Factor Binding Protein 5 as a Risk Factor for Preeclampsia

Preeclampsia was a specific syndrome in pregnancy that affects almost every organ.The main outcome of this study was the correlation of Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) level and Low Density Lipoprotein (LDL) level with preeclampsia incidence. Our study is an observational case control study with36 subjects are pregnant mother gestational age of 20 weeks until 40 weeks, pregnancy with single and life fetus, and consented to undergo the research. They were recruited from the Obstetric and Gynecology Department of Sanglah Hospital Denpasarfrom May 2019 to October 2019. Our analysis found that high IGFBP5 levels were risk factor for preeclampsia 13 times compared to low IGFBP5 levels (OR = 13.0; 95% CI = 2.6-65.2; p less than0.001). High LDL cholesterol levels were a risk factor for preeclampsia of 9.1 times compared to low LDL cholesterol levels (OR = 9.1; 95% CI = 1.9-41.4; p = 0.003).This study shown that high levels of serum IGFBP5 and LDL cholesterol in pregnant women are risk factors for preeclampsia.