Frequency of (G428A) Polymorphism within FUT2 Gene among Symptomatic UTI Diseases in Sudanese Patients

National Kidney & Urologic Diseases Information Clearinghouse (NKUDIC) reports that UTIs account for over 8 million doctor visits annually disease significantly affects females. Bacteria cause the vast majority of UTIs. Fungi or viruses can also cause UTIs. Symptoms of UTI depend upon what part of the urinary tract is infected; Single- nucleotide polymorphisms (SNPs) play a major role in the understanding of the genetic basis of many complex human diseases. Also, the genetics of human phenotype variation could be understood by knowing the functions of these SNPs. This study was carried out in Omdurman Miliary hospital aimed to determine the frequency of the (G428A) polymorphism among Sudanese UTI patients and explore if it has a correlation with age and gender or not. A total of 49 patients with UTI were enrolled in this study; blood samples were collected from patients and control in EDTA; genomic DNA was extracted from all samples using salting out method, allele specific PCR used to analyze the samples. The allele specific PCR showed that, 9(18.4%) of the 49 patients were homozygous "AA" while that 30 (61.2%) of the 49 patients were heterozygous (Guanine and Adenine alleles), and just 10 (20.4%) individuals were homozygous "GG". In conclusion, In conclusion, frequency of the FUT2 gene polymorphism among urinary tract infection was significantly high among female. Large percentage of Sudanese individuals has got a "GA" genotype allele in FUT2 gene; this large percentage could be according to human genomes variations worldwide.