Co relation of Lipid Profile with Proteinuria in Sickle Cell Nephropathy Patients for Local Area of Chhattisgarh

Pulmonary hypertension PH in sickle cell disease SCD is an emerging and important clinical problem. In a single institution adult cohort of 75 patients, we investigated lipid and lipoprotein levels and their relationship to markers of intravascular hemolysis, vascular dysfunction and PH. In agreement with prior studies, we confirm significantly decreased plasma levels of total cholesterol, high density lipoprotein cholesterol HDL C , and low density lipoprotein cholesterol LDL C in SCD vs. ethnically matched healthy controls. Several cholesterol parameters correlate significantly with markers of anemia, but not endothelial activation or PH. More importantly, serum triglyceride levels are significantly elevated in SCD compared to controls. Elevated triglyceride levels correlate significantly with markers of hemolysis lactate dehydrogenase and arginase both p 0.0005 , endothelial activation soluble E selectin, p 0.0001 soluble P selectin, p=0.02 soluble vascular cell adhesion molecule 1, p=0.01 , inflammation leukocyte count, p=0.0004 erythrocyte sedimentation rate, p=0.02 and PH amino terminal brain natriuretic peptide, p=0.002 prevalence of elevated tricuspid regurgitant velocity TRV , p 0.001 . In a multivariate analysis, triglyceride levels correlate independently with elevated TRV p=0.002 . Finally, forearm blood flow studies in adult patients with SCD demonstrate a significant association between increased triglyceride HDL C ratio and endothelial dysfunction p 0.05 . These results characterize elevated plasma triglyceride levels as a potential risk factor for PH in SCD. Dr. Prafull Dawale | Neha Jain "Co-relation of Lipid Profile with Proteinuria in Sickle Cell Nephropathy Patients for Local Area of Chhattisgarh" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-4 , June 2021, URL: https://www.ijtsrd.compapers/ijtsrd42438.pdf Paper URL: https://www.ijtsrd.commedicine/other/42438/corelation-of-lipid-profile-with-proteinuria-in-sickle-cell-nephropathy-patients-for-local-area-of-chhattisgarh/dr-prafull-dawale