The proof is in the pee: Dexmedetomidine induced diabetes insipidus

Dexmedetomidine induced diabetes insipidus is extremely rare phenomenon and typically seen in surgical cases. There are only a handful of case reports of dexmedetomidine induced diabetes insipidus in non-surgical settings. The mechanism of diabetes insipidus is unclear but thought to be secondary to inhibition of the neurohypophysis release of Antidiuretic Hormone (ADH). It is necessary to evaluate the development of diabetes insipidus in patients being treated with dexmedetomidine to avoid complications such as dehydration, hypotension, coma and death