ResearchBib Share Your Research, Maximize Your Social Impacts
Sign for Notice Everyday Sign up >> Login

PATHOGENETIC MECHANISMS OF DEVELOPMENT OF GENETIC RESISTANCE TO ANTIBIOTICS IN TREATMENT OF SEVERE INFECTIONS IN INTENSIVE CARE UNITS

Journal: Journal of the Grodno State Medical University (Vol.19, No. 3)

Publication Date:

Authors : ; ; ;

Page : 255-262

Keywords : Genetic resistance; antibiotics; bacterial strains; mutations;

Source : Downloadexternal Find it from : Google Scholarexternal

Abstract

Background: The dramatic rise in antibiotic consumption in intensive care units is a major public health concern. A widespread use of antibacterial drugs is the main factor in the resistance of pathogenic microorganisms to antibiotics. The increase in the number of resistant bacterial strains is largely due to the formation of new variants of resistance genes. Purpose: To analyze the results of scientific studies confirming the key role of bacterial genetic resistance in the mechanisms of antibiotic resistance development. Material and methods. A qualitative analysis of the Russian-language and English-language literatura sources concerning the aspects of the genetic resistance of microorganisms has been carried out. Results: It has been found out that antibiotic resistance in bacteria achieved by mutations in the chromosomal DNA leads to a significant increase in the number of multidrug-resistant microorganisms that become insensitive to antibiotic therapy. Conclusion: The growing prevalence of multidrug-resistant pathogens presents an urgent medical problem. The genetic mechanisms underlying bacterial resistance are key to antibiotic resistance. Annual research significantly expands knowledge about known and presumably new resistance genes, their mobility and evolutionary history.

Last modified: 2021-07-15 22:11:31