INFLUENCE OF MAGNETIC BLOOD TREATMENT ON THE DETOXIFICATION POTENTIAL OF HEMOPERFUSION THROUGH THE DOMESTIC HEMOSORBENT "HEMO-PROTEASOSORB" IN PATIENTS WITH SEVERE COVID-19

Background: The COVID-19 infection is a disease, in severe cases of which the mortality rate in the intensive care unit is 42-62%. Its main cause is the development of a "cytokine storm" and hypoxia in pulmonary injury. It has been proven that hemoperfusion through selective hemosorbents is effective for suppressing cytokine aggression. Considering the effectiveness of hemosorption in combination with magnetic blood treatment (MBT) in patients with sepsis, which is also characterized by endotoxemia and the development of a "cytokine storm", it is important to study the effectiveness of autohemomagnetotherapy in patients with severe COVID-19. Purpose: To evaluate the effectiveness of MBT in combination with hemoperfusion through the hemosorbent "Hemo-proteazosorb" in the severe course of COVID-19 infection. Material and methods: We studied the clinical and laboratory parameters of 36 patients with a severe course of COVID-19 infection, whose treatment included extracorporeal detoxification methods. All the patients were divided into 2 groups: "Hemo-proteazosorb" (19 patients) and "Hemo-proteazosorb + MBT" (17 patients). Results: Against the background of hemoperfusion through the domestic hemosorbent "Hemo-proteazosorb" in combination with MBT, a statistically significant increase in the levels of erythrocytes, hemoglobin, lymphocytes and the respiratory index was established. In the group "Hemo-proteazosorb + MBT" there was a statistically more pronounced elimination of IL-6 in comparison with the group where only hemoperfusion was performed. Conclusion: The inclusion of MBT in the standard protocol of hemoperfusion through “Hemo-proteazosorb” sorbent increases the effectiveness of the treatment of patients with severe COVID-19 by increasing its detoxification potential, improving the oxygen transport function of the blood, stimulating lymphopoiesis and improving the rheological properties of blood.