ENHANCED ANTI-INFLAMMATORY AND ANTI-MIGRATORY EFFECT OF HERBAL NANO-STATINS ON HEPG2 CANCER CELLS

Mushroom (oyster mushroom, Pleurotus sajor caju) is a rich depository of statins, HMG-CoA reductase inhibitors that also act as anti-cancer agents. In the present study, anti-inflammatory and anti-migratory effects of prior synthesized and characterized herbal nano-statins on HepG2 have been discussed for the first time. The results showed that herbal nano-statins were able to inhibit the NO production in dose dependent manner with 93.72 % inhibition at 80 μg/ml of nano-statins and it attained saturation if the dose is further increased. Bulk statins had less potency to inhibit the production of NO (30 % at 100 μg/mL) as compared to nano-statins. Nano-statins and bulk statins also inhibited the migration of cancer cells by 97.86 % and 53.43 %, respectively, at a concentration of 100 μg/mL. This study might bring in more insights to use herbal nano-statins as an alternative treatment to fight against various other types of cancers and other biomedical complications.