Role of Serum Uric Acid in Acute Ischemic Stroke: A Case-Control Study in India

Background. Stroke is a condition of quickly developing clinical signs of focal or global neurological disruption lasting for over twenty-four hours with no visible reason besides a vascular origin. Different risk factors are included for stroke development, like hyperlipidemia, hypertension, diabetes, and smoking. The current study was conducted to determine serum uric acid in acute ischemic stroke patients and evaluate its relationship with stroke severity. Method. An Analytical, Non-interventional Prospective study was conducted among 50 cases of acute ischemic stroke admitted in the medicine ward at Sadhana Kutir Hospital, Kim, India, over six months from August 2020 to January 2021. All patients who presented within twenty-four hours of the onset of stroke and who gave consent were included. Fifty normal healthy individuals are included as controls. Serum uric acid levels, along with other blood routine tests, were done. The GCS score measured stroke severity. Results. The mean age group in cases was 62.39±11.61 and in control was 60.18±14.72. In cases, mean blood uric acid was 5.41±1.26 and in control was 4.82±1.26; this difference was statistically significant at a p-value of 0.021. There was no correlation between the severity of stroke and serum uric acid levels. (p valve-0.2488). Conclusion. This study concludes that serum uric acid can be utilized as neurotic biomarkers in acute ischemic stroke patients. But stroke severity can not be predicted by its level.