Phototungstic Acid Catalyzed Synthesis of Benzo (h) Chromen-2-one3-methyl Carboxylate and Study its Anti-Inflammatory Property

The Coumarin heterocyclic ring is a common feature of various bioactive compounds such as Calanolides, lipid lowering agents. Coumarins, the most important classes of fluorescent molecules constitute important structural features present in a number of bioactive natural products. coumarin and its derivative are biologically activecompounds and widely occur in nature. Phosphotungstic acid (H3PW12O40) a commercially available environmentally benign catalyst non-toxic widely used for the synthesis of the substituted coumarin. Owing to the numerous advantages associated with cheap and non-hazardous catalyst, and also realizing g the importance of coumarin herein we would like to focus the eco ?friendly method for his synthesis of derivatives of coumarin using cheaper and commercially available acid catalyst Phosphotungstic acid (H3PW12O40) and also by the Knoevenagel condensation under microwave irradiation.This derivative of the coumarin was studied its anti-inflammatory activity. Anti-inflammatory activity of the newly synthesised Coumarin has been evaluated by calculating the percentage protection or percentage inhibition which was calculated by following equation.% protection= [O.D of control ? O.D of test/ O.D of control x 100Where O.D stands for optical density. This methodology offers significant improvements for the synthesis of derivative of coumarin with regard to yield of products, simplicity in operation and green aspects by avoiding toxic conventional catalysts and solvents. The coupling of microwave heating with solid phase catalysts in solvent-free conditions catalysis chemical processes with special attributes such as s enhanced reaction rate, Therefore owing the importance of Phosphotungsticacid (H3PW12O40) a facile catalyst used for the green synthesis of derivatives of coumarin. This paper focuses is todevelop environment friendly reactions, simple, highly efficient and high yielding protocol for the synthesis of Benzo (h)chromen-2-one3-methyl carboxylate using Phosphotungsticacid (H3PW12O40) as a catalyst. This compound is characterized by IR and NMR spectroscopy.