STUDY OF TROPHOBLASTS AND HISTOLOGICAL CHANGES OF FALLOPIAN TUBE IN TUBAL PREGNANCY AND ANATOMICAL CONSIDERATIONS FOR ITS EARLY RUPTURE

Fertilisation takes place in the lumen of fallopian tube, from where, aided by the ciliated columnar epithelium of the tube, the fertilised ovum makes its way into uterine cavity and the implantation occurs. The passage of fertilised ovum into uterine cavity is delayed or obstructed by developmental, mechanical or other defects which lead to tubal gestation. The incidence varies from 1 in 300 to 1 in 150 pregnancies and it contributes significantly to the maternal mortality and morbidity. Early diagnosis and therapy has helped to reduce the maternal death due to ectopic pregnancy. However, study on histological changes of early ectopic pregnancy are rather scarce and therefore, the present study was conducted on 25 patients of ectopic pregnancy specimens observed for the mode and extent of invasion of chorionic villi, and the histological changes in wall of the fallopian tubes to evaluate the causes of early tubal rupture as well as estimation of gestational age by the study of chorionic villi.