EVALUATION OF TOXICITY PROFILES OF DIFFERENT BRANDS OF PIROXICAM IN WISTAR RATS

BACKGROUD: , a non-steroidal anti-inflammatory drug (NSAID), has been identified to be one of such drugs with great potentials for abuse, addiction and death as well as complaints on the significant dissimilarities and variations of possible organ toxicities across different brands. This study aimed at evaluating toxicity profiles of different brands of in male rats. Healthy thirty (30) male rats, weighing between 180 and 230grams were procured from the animal house of the Pharmacology department, Faculty of Basic Clinical Sciences in University of Port Harcourt, Nigeria. METHODS: The animals were divided into six (6) groups of five (5) animals each. Group1-control group while group2 to 6 were treatment groups. Thereafter, the clinical dose (0.285mg/kg) of brands (A Brand, B Brand, C Brand, D Brand and E Brand) were administered on treatment groups. The analysis was done at the end of the experiment. RESULT: Reveals that, four out of the fives brands demonstrated significant (p<0.05) toxicities on liver and kidney. Two of the brands has predilection for liver toxicity while another two exhibited kidney toxicities. The heart organ was spared from toxic effects of all the five brand understudied. CONCLUSION: The degree of organ toxicities with different brands of varies, however, certain brands tend to have toxicity predilection for either the liver or kidney.