QUALITYCONTROL OF CLOXACILLIN SOLD IN NIAMEY CITY BYTHIN LAYER CHROMATOGRAPHY

The objective of this study is to control the quality by Thin Layer ChromatographyCloxacillin used in Niamey cityafter carrying out a prospective survey on antibiotics commonly used in health centers and at the same time purchased from street vendors. This quality control aimed to investigate on eleven samples distributed as following as: five samples are from pharmacies five samples are from street vendors and one sample is the specialty which is used as reference to check their active ingredient. The different reagents used in this research are: Hydrochloric acid (HCl) 37 %, acetone, distilled water, ethyl acetate and acetic acid. All samples migrated in proposed diluent. This shows that all samples contain the active ingredient substance of cloxacillin. The percentage of the active ingredient were calculated as per protocol of Clarkes analysis of drugs and poisons in chemistry guidelines. It varies from 96.87 to 97.91for the pharmacies and 97.91 to 104.17for the street vendors. According to the results of the different frontal reportspercentage, all of themmeet the standards required by the WHO which is 90 to 110 %. This technique can be used for practical work or tutorial and laboratories where drug quality control mechanism is not often checked.