EVALUATION OF HISTOLOGICAL CHANGES IN CHRONIC CHOLECYSTITIS AND CHOLELITHIASIS OF HUMAN GALLBLADDER

Introduction: It is appear to be increasing in incidence over part couple of decades in India and western world due to increased intake of fatty and high calorie diet and increased consumption of alcohol. Cholecystits and cholelithiasis are very common particularly in fatty, fertile and female of forty to fifty. Various sign and symptoms like severe pain in Murphy’s point in right upper quadrant of abdomen , bilious vomiting , mild to moderate increase in temperature , obstructive jaundice , loss of appetite are present in these disease . Aim of study: The purpose of the present study is to compare the histological changes in the wall of human gall bladder in Cholecystits and cholelithiasis. Material and methods: Gallbladder of 100 patients of both sexes, aged between 12 years to 80 years was taken for present research work who underwent cholecystectomy for cholelithiasis with cholecystits. The gall bladder biopsy was processed for histopathological examination. Hemotoxyllin and eosin staining was done for microscopic observations. Results: The observations showed focal and diffused ulceration of mucosa and inflammatory cells infiltrate in sub epithelial layers. Fibrosis and thickening of the perimuscular layer with muscle hypertrophy were observed in maximum cases. The congestion of blood vessels and hemorrhage were also noted. Discussion: The conclusion of study is to demonstrate predominate alteration in specific layer of diseased gallbladder and to compare it with each other and normal one. Once histopathological changes occur they alter the normal tissue pattern and can induce the carcinogenic progression and metastasis. The advantage of this work is early differential diagnosis between the two and two give effective treatment as early as possible.