The Role of Gedunin Against Aquaporin 2 for the Possible Treatment of Diabetes An In Silico Study

Diabetes is one of the major causes of death in the world, affecting around 422 million people or 8.5 percent of the worlds population . Diabetes mellitus, or diabetes, is a disease that causes excessive blood sugar levels. Diabetes mellitus is a condition where a person does not produce enough insulin or does not link directly to insulin, and resulting in excessively high blood sugar glucose levels. Diabetes is classified into several types Prediabetes, Type 1 diabetes, Type 2 diabetes and gestational diabetes. In diabetes research, numerous bioinformatics technologies are used. The current research was carried to study the effect of naturally occurring compounds against Aquaporin 2 as the target protein molecule with the help of molecular docking for diabetes diagnosis. AQP2 is found in the apical cell of the main ducts of the kidney and in the vesicles intracellular in the cells. Docking experiment were performed out by using aquaporin 2 4nef . The technique of molecular docking was utilized to investigate the potential of naturally occurring compounds such as aglycone, gedunin, and harman with the target protein Aquaporin 2 4nef . In diabetes, gedunin may function as a therapeutic drug against the disease causing protein Aquaporin 2 4nef . Further research and then certain clinical and pre clinical studies may be allowed to discover drugs that can be used to treat diabetes. Ayushi Chaudhary | Noopur Khare | Tripti Bhatnagar | Abhimanyu Kumar Jha "The Role of Gedunin Against Aquaporin 2 for the Possible Treatment of Diabetes: An In Silico Study" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd43788.pdf Paper URL: https://www.ijtsrd.com/biological-science/biotechnology/43788/the-role-of-gedunin-against-aquaporin-2-for-the-possible-treatment-of-diabetes-an-in-silico-study/ayushi-chaudhary