Gouania Longipetala Aqueous Extract Exhibits Antiestrogen Activities and Activate Estrogen Receptors in Ovariectomized Wistar Rats

Previous studies showed that G. longipetala aqueous extract GLAE induced estrogenic properties in ovariectomized Ovx rats. The present study aimed to assess antiestrogenic activities and signaling pathways of GLAE. For that, two pharmacological tests were used to evaluate GLAE effects in ovariectomized rats treated with estradiol valerate E2V and a pure antiestrogen ICI 182.780 . Animals were either sham operated or Ovx. 3 day uterotrophic assay was carried out in Ovx adult Wistar rats and GLAE effects were evaluated on the genital tract and mammary gland. Results showed that GLAE reduced significantly vaginotrophic and mammotrophic effects of estradiol valerate. Indeed, GLAE reduced by 68.72 and 62.66 respectively for 45 and 180 mg kg the vaginal epithelial height of E2V Ovx rats. Besides, ICI 182.780 cancelled estrogenic activities of GLAE in both genital tract and mammary gland. Overall, Gouania longipetala aqueous extract activates estrogen receptors to induce estrogen activities and exhibit antiestrogenic properties. Mengue Ngadena Yolande Sandrine | Dzeufiet Djomeni Paul Désiré "Gouania Longipetala Aqueous Extract Exhibits Antiestrogen Activities and Activate Estrogen Receptors in Ovariectomized Wistar Rats" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd43840.pdf Paper URL: https://www.ijtsrd.com/humanities-and-the-arts/psychology/43840/gouania-longipetala-aqueous-extract-exhibits-antiestrogen-activities-and-activate-estrogen-receptors-in-ovariectomized-wistar-rats/mengue-ngadena-yolande-sandrine